One difference is in the size of the blocks - the Jane Stickle quilt block size is 4.5" and Farmer's Wife is 6". The Jane Stickle quilt was made during the Civil War, the Farmer's Wife quilts in the 1930's. The blocks are different, but both are samplers. The Jane Stickle quilt also features a distinctive scalloped border of cone shaped blocks. The Jane Stickle quilt would be more complex and difficult IMHO.