Thanks for the replies, everyone!
I do know what stitch in the ditch is, and I have done it on several quilts. I'm quilting on a Janome Magnolia with a 6" harp, so I don't want to be turning a 90" quilt inside that space using a walking foot to SITD that one seam if I don't absolutely have to. That's why I'm wondering if it's necessary if I'm planning to do some significant quilting.
It's purely that one seam going around the outer edge of the colored portion of the block that I am worried about. It's a 24" block, so it's pretty big! If I don't quilt over that seam, will it wear worse over time? If anyone has any particular experience with doing this, I'd appreciate it

I've outlined the seam I'm asking about in this picture.
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Thanks!