If blood, peroxide on a Q tip will work (rinse area well afterwards). If ink, alcohol will remove it. I have great success with blue Dawn mixed with a little water and applied to food stains with toothbrush and then soaked in cold water for about 8 hours. I also used Restoration this weekend on white and off white doilies and clothe napkins and loved it. Stains, even set in ones, came out. Uses warm water but you would have to soak entire quilt in a bath tub or a non- efficiency washing machine (needs lots of water). I just ordered more on AmAzon. good luck!