I've been systematically purging my house because our goal is to move in 2 years. I'm examining all the clutter with the questions, "Do I love it?" "Do I use it?" "Is it in my way or does it bring me down emotionally?" And this one: "Would I want to take it with me to my next house? Is it worth the weight the moving company charges by the pound?"
So far I've made progress in my dining room, kitchen, sewing room, guest room, and master bedroom. Today I tackled the second half of an upper shelf in my closet. All sentimental items (baby books, photos, kids' artwork, greeting cards) but I have gotten much more efficient at purging. It feels good. Really good to be honest with myself about my stuff. If I love it, I keep it. If I don't, I decide to rehome it. I'm not overthinking nearly as often as I used to. I don't miss anything I've gotten rid of.