I have many times split the 45 inch wide fabric in half lengthwise and added blocks up the middle. These are not blocks with a huge amount of seams. Also my tops are fairly simple with no tiny Bonnie Hunter type pieces. I quilt on an ancient HQ16 and never had a problem.
It is great for those tops are are 8-10 inches wider than width of fabric. And it uses up orphan blocks. I am mainly a charity quilter and I things it adds to the whole picture.