I no longer use poly cotton blends because I can't stand the smell when I iron them but I did use them in the first few quilts I made. One was a baby quilt that had every level of fabric in it from the $1 a yard Walmart fabrics that are poly/cotton blends to high end quilt shop fabrics in it. That quilt is almost 10 years old, still being used, and still in one piece. The only thing I would caution is to lower the temp of your iron when pressing poly blend fabric.
Cari