Just be careful what pen-inks you use.
For my youngest son's wedding, I cut out 300 fusible-interfaced batik hearts for guests to sign. I also provided an assortment of markers-- extra extra fine point industrial permanent Sharpie, Frixion,and Gelly Roll pens. The intention was to applique the hearts onto a border on the back of the quilt (a batik Double Wedding Rings). I kept the signed hearts in a bowl on my cutting table and one day I knocked a glass of water over, the autographed hearts got wet, and the ink on the hearts signed with Sharpie markers ran creating a big black blurry mess over all my hearts. I was devastated. One of these days I will return to this quilt and finish it and I am thinking I may just make some more batik autograph hearts and embroider the names of the attendees on them or abandon the idea altogether and just finish the quilt. Either way, I was shocked the Sharpie ink ran. Who knew?