I have used Gutterman and YLI and like both of them. I think the older monofilament threads were more brittle and didn't work out as well. I've made a lot of kids' quilts with invisible thread and only one I've had to repair the quilting which was on the bias (cross-hatched). I do keep my invisible thread in a plastic baggie. This may not be as important nowadays as it was when the invisible threads first came out though. And, yes, invisible on top and regular thread in the bobbin. Have never heard of using invisible for hand quilting. I haven't tried it but would anticipate that it might tangle and perhaps even shred with the process. It's hard enough to untangle thread that I can see!