I have used them in t-shirt quilts several times--I normally prefer woven ShapeFlex stabilizer for t-shirts, but for them I prefer a lightweight non-woven Pellon fusible--check as there is one that can be used with poly fabrics at a lower temp (but I don't remember the #). The non-woven seems to back the holes typical of these shirts better. Quilting them is not a problem (I do a simple meander and loop on the long arm) but often these shirt either have heavy-duty embroidered on (stiff) lettering or that "plasticy" logo--I avoid both. Good luck!