I have done it several times. Right now have a quilt that I plan on quilting real soon & I plan on using muslin for the batting. I am gonna use (prewashed) flannel for the back & I thought it would be soft enough. I am really only gonna use the cotton muslin so the teal flannel doesn't show through the white fabrics that I have in a few places on the front. I am only gonna use 1 layer of fabric instead of batting.