Why does she need to put a zipper in? My husband has a port and he never had a problem with them accessing it. He wears a regular button front shirt and they simply unbutton a couple buttons and have easy access. As long as he has a button front shirt he does not have to worry. If you put zippers in a shirt as you have described she will be wearing the same shirt or shirts day in and day out. The placement of the port is usually near enough to the neck area so it causes no problem being able to access it. I have never seen anyone with one of these shirts with zippers. If this is what the lady wants that is fine but I see no need to go to all this work unless you are sure this is what she really needs. After starting the chemo she may find that such a shirt is entirely unnecessary.