I don't know about skunk smell, but I cad a quilt that was peed on by a cat, then put in storage for at least 5 years. The smell was eye-watering, and I was sure it would never come out, and almost threw the quilt out. I washed it with Arm and Hammer Washing Soda, and was shocked to find the smell completely gone. At about $4 a box at WM, it might be worth a shot. Good luck