The short answer to your questions is no! I would venture to say that even quilters who have won top prizes in top quilt shows have imperfections in their quilts. After the quilt is washed you will find that so many of the things you see as mistakes will just blend right in & not ever be noticed. When I first started quilting & gave a quilt away I would always point out my mistakes to the recipient. Finally I came to my senses & realized that most people don't even see the obvious mistakes that I make on quilts & more important than that, they don't care about mistakes...only about the fact that I made them something special. So my suggestion to you is don't ever apologize for a mistake on a quilt or point it out to others. You will feel much better & so will the one who receives it.
Just do what makes you happy & enjoy your new found hobby.