Quilts that are going to be used/washed a lot get machine bound by sewing to the back and then bringing the 2 1/4" binding around to the front and sewing it down. It really is a learned skill and once you've got it, it is a real time saver and looks nice.
Quilts that are for gifts or shows, I hand sew on the back.
I'll have to try the flange binding again... The one time I tried it the corners came out badly.
Watson