Gladly, I'm able to continue my projects while on the road.
You'll need a nice flat pillow to place it on your knees, and it works if the road is smooth enough. If not... well, just trying to keep everything handy and not falling in the cracks of the seats and console or under my feet would be a problem for me. Try to take small and hand sewing projects with you, unless you have an RV when you can place a sewing machine. Store your supplies in a zip bag and put it in a car door pouch.