Currently, I am thinking of trading my smaller machine for a more up-to-date model.
I don't know either machine you have mentioned, so can't specifically answer your question.
However, some considerations I am already thinking ...
* Is your At Home machine, Brother? or Janome? ... similarities of operation may make it easier to switch from one machine to the other
* Would the feet, bobbins and accessories be interchangeable between the two?
All things being equal, those answers would probably sway me towards a Little Sister machine!