The simple answer is yes - I mix my seams. Longer explanation - I depends on the bulk and how many seams intersect. I prefer them to all be to one side or the other (I do not adhere to press to the dark always). If I can get them all "going" in the same direction at an intersection and can spiral the seams so that it lays nice and flat, I am very happy. If trying to do that I end up with a bulky lumpy mess somewhere else on the seam I press open.