I would look within your community as to what the needs are. Is there a veterans center that is in need? What about the cancer treatment center or dialysis clinic? Or the homeless shelter?
My friends and I have donated many quilts to all of these charities. Our community built a shelter for homeless veterans, so we made and donated quilts for every bed. One of our hospitals gives a quilt to every terminally ill patient, the thank-you cards from the surviving families would break your heart. The cancer center wouldn't take the quilts themselves because of the added work of washing them after every patient, so we gave the quilts directly to the patients. There are also well-known national charities, such as Linus quilts and Quilts of Valor, I prefer to keep my donations within my own community but you may find it rewarding.