For years my donation quilts went to Ronald McDonald house through my guild's program. I don't know about now but back then the siblings of the patient could get tops too so they needed all sizes and subject matter. We had a project corner at the quilt show for kids (of all ages) to draw pictures that we would put together at the show and throughout the year.
The ladies I quilt with on Tuesdays belong to a guild that has two projects, one is a "children's corner" and they take all sorts of quilts and clothing etc for up to age 18. The other is preemie quilts for one of the local hospitals. I've been giving them my donation tops for the last year.
Other groups in this area help out hospitals, whether for children or cancer or dialysis or other reasons. There is always the Red Cross.
One thing really needed around here are little bags of supplies for the homeless or extremely low income for personal supplies such as deodorant and toothbrushes. I've been part of groups that did everything from making the bags, shopping/donating the supplies, filling the bags, taking them to the shelter/parent organization.
I know some people don't like United Way, my area used to have a phone number to connect volunteers looking for the right group to support. Catholic and Lutheran social services also had similar contact numbers, and even if they don't it's amazing what a call to a switchboard can do.