You will find lots of advice from board members in the post I made below asking about free-motion quilting tips.
For me personally, this is what I do: straight stitch plate, Feed dogs up...stitch length and width are set to Zero, Supreme Slider on the machine bed to allow the quilt to move smoothly across the machine bed. Support the quilt with tables if needed to allow you to move the quilt smoothly. Chair height is important so you can keep your arms at a comfortable position. It helps to make a practice quilt sandwich using the thread, batting and fabric from your quilt. Have fun!
Please Give me your favorite tips for Free-Motion Quilting Success