Depends on machine, on my 12' HQ Fushon with robotics, it would be a real simple thing to do. Just turn the computer on and use the electronic channel locks and stitch away. I could also use the manual channel locks (it's a rubber piece that holds the wheels from rolling) but if I push hard, I can overcome them.
Most robotics have the channel lock feature as it's a easy way to check that you've got the quilt mounted straight.