I have quilted quite a few quilt sandwiches on a Bernina B700 embroidery machine with usually a 400x210mm hoop. Most have been E2E continuous longarm designs that I either digitized from an image or downloaded as a longarm file with usually a qli format. I use Embird for all the digitizing and conversiton to the exp files that are needed by the Bernina. I also do the custom quilting with blocks, sashing,borders with picture framing etc. Although I could do larger quilts than crib size I normally do not as that would feel like work and I want this to be fun.
Normally I use Glide, Isacord etc #40 thread top and bottom, but also have used #60 Bottomline for blending or 50/3 cotton for a heavier look.
I always baste a 4" strip around the top and make the batting and backing that size to allow for hooping.
I could go on and on but I'll stop before your eyes glaze over.