I recently backed a quilt in fleece. I took my quilt to a long armer to be quilted. The fleece makes the quilting stand out. It's a poofy look, which was great for a kid's quilt. However my mom did the binding for me from the same quilting cotton used on the quilt top. According to her, using a fleece backing made the binding difficult because of the thickness and because you can't get your iron as hot with fleece. Also, we had to cut much wider binding strips to account for the thickness of the fleece.