Lisa, I'm dealing with a different set of issues which for me is vision related but I think can help maybe some for you. There are many things we can do that are fun and cool and beautiful that isn't dependent on tiny little pieces. Unfortunately, most of my techniques are based around cutting large and trimming down so I haven't been thinking in your direction.
So maybe pick something that doesn't require much accuracy like string quilt projects. Can be a good way to get rid of some things! You can still sew the strings/foundation piece/however you want to do it, and then trim them down when cutting is easier.
I find straight lines easiest. Maybe kit out a log cabin while you are cutting?
What about pressing, that position/motion may prove slightly problematic to you, but if you don't usually press it shouldn't be much of an issue.