Pick a fabric with a very large print. I made one with fabric I fell in love with, but in the end didn't have the variety of blocks I'd hoped for. It as a black print with pink roses, with a secondary background print. I think it didn't have enough black space between the roses to work like I'd hoped. I also sewed my into rows, which meant a lot of layout planning as each row included 3 of the 6 block sections.
I did another using a white/gray/black print. I knew it wasn't going to give a of variation to start with, so I used White to turn it more into "stars" with different centers and not the typical OBW quilt. I really liked how that one turned out. Because I added the white, I sewed the 6 sections together and added one white to each side, and then sewed those sections into rows.
Since then I bought some fabric that is ocean blue with very large orange/gold fish. This one has more "open" space between the fish and I'm hoping it will give me more variation. Not sure when I'll get to it though.