I used to have my sewing area arranged so I could sit and spin from machine to work surface to ironing board, but just because you can doesn't mean you should. I had to deal with a lot of repetitive stress issues being a production office worker and careful body positioning is just one.
I have a small house but a tolerant husband and I have now deliberately moved things out of the sewing room and into the house. I do my layout on the queen sized bed in the master bedroom. My sewing room is the next small bedroom. The ironing board is currently set up in the living room, and I use the dining room table as my cutting area. It may not be much in concentrated movement, but I get my steps in through the day!
The other thing I have to make a conscious issue to do is change tasks every 15 minutes or so. For me, that usually means I'm working on a certain number of units at a time, I do believe in consistency so there may be multiple sets of repeat stages. So, I'll sew for about 15 minutes and then get up and press, go back and sew, and repeat. That also helps me break my ironing down into small stages, because I do not like having to do hours of it at a time!