I cannot use any kind of thimble when hand quilting. I have good callouses on both hand. I frequently try new techniques but since I am left handed they rarely work and I can't seem to rethink for the left hand. I do a good deal of hand quilting and find it relaxing. Hand quilting for many years not I rarely poke my hand from the underside of the quilt any more. It takes practice and patience but you will get the hang of it.