I've made several like this and did what Ckcowl explained. On those that you cut the 2x2" you might want to think about just appliqueing the small blocks onto another tee (if room). I recommend you either use graph paper (or if you have EQ8 use the custom layout setting) and work so that you develop rows or columns by using sashing around your blocks to bring them to the largest block in the row/column. Not really hard to do, but definitely takes time as it's like working a puzzle.