The only time things get re-arranged at this point is when I get something different, like a completely different piece of furniture. I'd like to put the bed on the opposite wall and switch the master bedroom, hubby likes it the way it is. Eventually I'll actually paint the room and then I'll go ahead and move everything the way I want to, think the hubby will find out it will be just fine.
I don't change my art often either. Once it gets wall space, it pretty much stays.
One of the things that determines my layout is the electrical outlets and that we have various animal habitats on the most flat surfaces. The reptiles need their heaters and things, once furniture has a tank on it, it sort of loses the furniture appeal...