I appliqué a similar colour square over the hole, then put a tad of batting under that and on the backside I appliqué another square. Then I try to stabilize the patch with a few quilting lines. The quilt my grand doggy uses now was originally patched with matching fabrics, now when she visits (she uses the quilt as kind of a pacifier) so I have taken to just patching it with whatever fabric is available.
