For consistency, I typically like to do all of a step at one time and I work assembly line fashion. That starts with cutting. I might break it down into combinations, but I prefer to start with a huge stack of fabric. Then a slightly smaller stack of cut fabric which gets turned into strips. Then I start putting combinations together. And then I press each step. Put the next set of combinations together, etc.
I don't usually paper piece and I don't like one block at a time construction, but even still, I will connect all pieces I can in round 1, etc. In the last couple of Bonnie Hunter mysteries, although I was able to do original combines in large groups, when it came to putting the sets together into blocks I found I could only deal with about 4-5 blocks at a time without getting too confused or having to spend too much time matching things up. After two years, I've gotten much better on my organizational techniques (as well as clamps!).
But yes -- when I'm working on a queen sized project I might be doing 1k HST or something awful. I will go as long as my thread and prepared fabrics last. I am also a pinner so that gives me a stopping point. My current project has 32 fan blocks each with 8 fan blades. First round, all blades connected into what I call 2-fers, then the 2-fers connect into quarters (confusing because they are half the arc but have 4 parts), then the halves into wholes. All 32 being working on at the same time.
When I do have a huge slog of pieces, I try to break it up into 15 minute chunks which is actually quite a bit of sewing (and longer than my pins usualy last), then pressing, then pinning the next set and so forth.