I find I often work in numbers divisible by ten. I then keep combining groups and clip them together in tens. So, if I am making four-patches, I will make 50 two pieces, press then join to make 25 four-patches, press and repeat. I clip the four-patches together in groups of 10.. That way I don't waste time counting and recounting how many I have finished.
I had friends making the OMG quilt this spring and they would make "garlands" of 100 plus of those little pieces. It all depends on what works for you and how many pieces you need.