I mostly do "raw edge" applique. I fuse Soft n Fuse to the fabric, cut out the shapes then use the buttonhole stitch on my machine to sew them down. I'm working on a Lori Holt applique quilt right now and am using this method. I've never had a problem with the appliques coming undone in the wash or with use. I'm too impatient to sew everything down by hand, although I love that look.