I love homespuns and have made many quilts using them alone or combined with regular quilting cottons. I do recommend using a spray starch or spray sizing both available in the laundry section. I prefer the sizing. I cut multiple layers as with any cotton fabric and a 1/4 seam. I do reduce the stitch length a bit. On my machine I drop from a 2.5 to a 2.0. I don't worry about the direction of plaids especially since they are geared to a more primitive look. I'm not completely sure what you meant with your cutting and sewing directions but go for it! I can send photos of some of mine, the ones I still have, by email if you need some inspiration. Have fun!