Sending you comfort and peace in the shadow of angels wings..they're always there!!!!......sure sounds like depression (been there). As for your kids, you nurtured them...and now nature has taken over. They're adults, and make their own choices...you have no hand in it any more...as for your sister, rather thoughtless I'd say. You reap what you sow...you DO have other plans right? Taking care of YOU? And depression doesn't NEED a THING to make it happen...you CAN mature in to lacking a chemical in your brain...just like people acquire diabetes. No shame in it...have a chat with your Dr and keep us posted. We DO care..that's what friends do.