I iron my binding in half at the ironing board. As I iron a section, I fold it back on itself so that I end up with the entire length of the binding folded around itself like a cinnamon bun. Then I lay my quilt out on a table and use the quilt clip thingies to clip it to the front of the quilt all around. Once it's clipped on, then I take it to my machine and sew it to the front. Works like a charm and no more twisted/tangled binding while I'm trying to sew it on.
Rob