I've used digital prints and mixed them with traditionally-printed and dyed fabrics with no problem. The colors are quite vivid.
The only issue that I've had, and I know other quilters have had the same issue, is that when quilting the fabrics, you can sometimes get what looks like a run or pull in the fabric. What' happening is the needle can spin a thread sideways or upside down as it moves through the fabric, and since the digital colors are printed only on the top of the fabric, this results in a white thread showing. I want to wash it to see if it resolves itself but haven't had the right project at the right time yet.