I personally like the individual square quilting for that size block. I like a 1 3/4 inch quilting line spacing as it keeps the blocks a bit puffy. I do sew each seam to stablize the seam but those are the only full seams top to bottom and side to side. Also I do the first--center-- block top to bottom and the 4 around it side to side. I sew them on the machine after I've basted everything by hand in an embroidery hoop. Hope this gives you some ideas.