I think it's a pretty quilt, too! I camped with a friend who had a double-knit polyester quilt very similar to this one. It was super warm and I was very thankful she had it!
I agree with the others - tying this quilt would be a good way to finish it. I'm assuming you were planning on quilting it on your DSM, is that what you meant by "manual"? I don't think you'd get skipped stitches from polyester, unless you were using a needle that is too small and flexes because of the pushing/pulling the quilt through the harp. The much more likely issue is that the knit will stretch as you maneuver it, and you will get tucks and gathers.
I once saw a gorgeous quilt Kaffe Fassett had made (or commissioned), it was in one of his books. It was "tied" by sewing machine, using the decorative stitch that looks like a single snowflake. Very simple, but effective and attractive.