I have used all types of batting, including high loft poly, and always heat set each side with a dry, medium heat iron. I don't put pressure on the iron, just a quick pass over. I can heat set and flip right away and baste the other side. I have basted up to 6 quilts (throw size) in one day. I do let the finish drying overnight before I begin the quilting process. I just pile them on top of each other! I thin the glue (maybe 6 to 1) with water. Just enough to get a smooth drizzle. Apply in a grid pattern and smooth with a sponge brush. I have never encounter a wrinkle on either side! My HQ Sweet Sixteen has never had an issue quilting it. I would never go back to pins or sprays!