I quilt on a sit-down HQ Sweet Sixteen. Since my major challenge is managing the weight of the quilt, I quilt in quadrants, starting from the center, and always working in the lower right quadrant, having most of the weight of the quilt resting on a table over to my left, and up above the quilting area. So I start at the center and kind of create a rough diagonal area of quilting that expands as I get to the outside edges. I then rotate the quilt so I am once again working in the lower right quadrant, starting at the center. This wouldn't do for people doing more formal quilting, but it works for my casual style.