I can say that while I watch the weave and density, in my mixed scrap quilts (commercial) homespuns have held up at least as well as standard woven cottons. Sometimes better!
In a quilt I did for my husband before we were married/he moved to be with me, he overwashed the top and wore out the back which had to be replaced. The homespuns in that are still intact, although now a couple of the standard woven fabrics have frayed.
My preference was to make projects with mostly homespun, but to offset that by say Kona Cottons, but I have mixed them in with general scrap quilts.