I need to see things in color rather than using graph paper. I would decide on a generic size block, say 12" or 16" finished. Then I would group blocks together, perhaps by color or design, and set them together into 12" or 16" blocks. It might involve adding a neutral filler or skinny sashing in between. Or maybe fill in with some checkerboards or flying geese to get things up to size. Then I'd put the blocks together.