I have the J350 Miyabi which I believe is the newer version of the 2200QVP. I get good results with a Gros-Beckert 110/18, which is a #4, needle when using 40wt thread. On my machine, I adjust the eye to the 5:30 postion. I usually stitch in cruise mode. I have to say, I've not been happy with precise mode but it could be me and not the machine - I am a ruler quilter and precise just doesn't work well with all my starts and stops. I adjusted my hopping foot to be a credit card width off the fabric when in the down position and that seems to be a good place. Finally, be sure that your fabric is not to taught as that can lead to skipped stitches, but that would most likely happen in all modes not just the two you are having diffculty with. Baste for me works fine so I don't have any ideas for that. Good luck. It is most likely something simple and not a timing issue.