What I found in my earlier machine quilted projects (20-30 years ago) was the wear and tear as they aged were not in the seams, but rather in larger areas of un-quilted fabric. I think part of this is from the subtle rubbing between the top and batting (maybe especially when washing?), and some simply that it is just not secure. I was living under severe allergy protocols for a number of years which meant monthly washing of the bed quilts.
On the other hand, if you aren't washing them that frequently or plan to use them forever, doesn't hurt really to try what you want to do. And you can always go back later and add more quilting if you wish.
Short form translation: I would not recommend going 10 inches, I'd consider 6.