I recently asked for some easy patterns for inexperienced quilters and one of them that I was rather taken with was this one:
https://web.archive.org/web/20091007...peedyBaby2.pdf
That's for a 45" square baby quilt but it would make a great choice for a large quilt using additional blocks. If you had a fairly large scale print for the center square(s), you can piece the borders of prints. I have a piece of really lovely dark blue, maybe the design thought was pillow forms? But I will be taking those and adding borders for what I hope to be a quick but stunning top.