My quilting room is the dustiest one in the house
i have always attributed it to the fabrics, threads and batting shedding just that much every time they are cut or fooled with. I don't mind. It is easy enough to dust. I keep a Dyson stick vacuum in that room ready to use. I have another one downstairs.
In don't have any ailments or allergies
except seasonal ones so for me it is just the way it is