Oh my goodness -no - do not trim them. (just my opinion lol!!)
the .25 (imho) is not a big issue - those can be sewn tog with out too much issue. The .5 may be a bit trickier - can you go back ans "let out" a few seams? or press them really well?
Another option is to stay stitch the edge of the larger blocks just outside the 1/4 " seam line. This will sometime make them a little smaller easing into the smaller blocks. (this is somewhat akin to the easing technique that seamstresses use for sleeves).