May as well throw in my two cents. I have hand quilted 3 full size bed quilts and am currently on my 4th. I have machine quilted loads of baby quilts, some wall hangings and a sofa quilt that was pretty close to twin size. Of the handquilted quilts, 1 and 2 I used a poly bat. I found I could get the smallest stitches with a poly bat. Unfortunately I don't remember what brands I used and on my 2nd the batting started to fall apart on edges so I was very disappointed with it and thought I had sworn off poly. Quilt 3 I used Heirloom 80/20 and while I loved the look and feel of the finished quilt I found it difficult to rock the needle to get small stitches, so I simply increased my SPI and bent a buttload of needles. The one I am working on now has quilters dream poly and I am really liking it. Machine quilting I really like W&N or Hobbs 80/20. I have hand quilted embellishment on W&N baby quilts and again it hand quilts ok but I can not get as tiny a stitch as I can with a poly. I have never tried wool.