This quilt was 36 x 36, so not so large. I haven't tried anything larger (yet). I did all the across sashing, blocks and top and bottom borders and then took it off the frame, turned it 90 degrees and put it back on and did the other two borders and sashing. I know from reading on the Juki yahoo group, a lot of people do half and then take them off, turn completely around and start quilting from the other end.